When loss is gain: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40
نویسندگان
چکیده
منابع مشابه
Loss of presenilin function is associated with a selective gain of APP function
Presenilin 1 (PS1) is an essential γ-secretase component, the enzyme responsible for amyloid precursor protein (APP) intramembraneous cleavage. Mutations in PS1 lead to dominant-inheritance of early-onset familial Alzheimer's disease (FAD). Although expression of FAD-linked PS1 mutations enhances toxic Aβ production, the importance of other APP metabolites and γ-secretase substrates in the etio...
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A number of studies have demonstrated a linkage between renal dysfunction and adverse clinical outcomes in both acute and chronic heart failure.1–3 Heart failure treatments can affect renal function in a variety of ways, with decreased glomerular filtration rate (GFR) during treatment often denoting a poorer prognosis.4–6 Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor...
متن کاملRenal function and heart failure treatment: when is a loss really a gain?
A number of studies have demonstrated a linkage between renal dysfunction and adverse clinical outcomes in both acute and chronic heart failure.1–3 Heart failure treatments can affect renal function in a variety of ways, with decreased glomerular filtration rate (GFR) during treatment often denoting a poorer prognosis.4–6 Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor...
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Nearly all polysaccharides in plant cell walls are O-acetylated, including the various pectic polysaccharides and the hemicelluloses xylan, mannan, and xyloglucan. However, the enzymes involved in the polysaccharide acetylation have not been identified. While the role of polysaccharide acetylation in vivo is unclear, it is known to reduce biofuel yield from lignocellulosic biomass by the inhibi...
متن کاملWhen gain-of-function research is not "gain-of-function" research.
T here is ongoing discussion among the scientific and biosecurity communities over how to address concerns about “gain-of-function” (GOF) research using highly pathogenic agents [1–3]. The discussion has mainly centered on previous work by Yoshihiro Kawaoka’s group at the University of Madison-Wisconsin in the USA [4] and Ron Fouchier’s group at Rotterdam University in the Netherlands [5]. Both...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2007
ISSN: 1469-221X,1469-3178
DOI: 10.1038/sj.embor.7400896